Tuesday’s game features the Louisville Cardinals (21-6, 14-2 ACC) and the Virginia Tech Hokies (12-15, 7-9 ACC) squaring off at Cassell Coliseum in what should be a lopsided matchup, with a projected 78-67 win for heavily favored Louisville according to our computer prediction. Tipoff is at 9:00 PM ET on February 25.

Based on our computer prediction, Louisville projects to cover the 10.5-point spread in its matchup against Virginia Tech. The over/under is listed at 146.5, and the two teams are projected to come in below that total.

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Louisville vs. Virginia Tech Game Info & Odds

• Date: Tuesday, February 25, 2025
• Time: 9:00 PM ET
• TV: ACC Network
• Live stream: Watch this game on Fubo (Regional restrictions may apply)
• Where: Blacksburg, Virginia
• Venue: Cassell Coliseum
• Line: Louisville -10.5
• Point total: 146.5
• Moneyline (to win): Louisville -549, Virginia Tech +400

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Louisville vs. Virginia Tech Score Prediction

• Prediction:
  Louisville 78, Virginia Tech 67

Spread & Total Prediction for Louisville vs. Virginia Tech

• Pick ATS: Louisville (-10.5)
• Pick OU: Under (146.5)

Louisville’s record against the spread this season is 16-11-0, and Virginia Tech’s is 12-15-0. The Cardinals are 10-17-0 and the Hokies are 13-14-0 in terms of hitting the over. The two teams combine to score 149 points per game, 2.5 more points than this matchup’s total. Louisville has a 6-4 record against the spread while going 9-1 overall in the last 10 contests. Virginia Tech has gone 5-5 against the spread and 4-6 overall in its last 10 games.

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Louisville Performance Insights

• The Cardinals have a +282 scoring differential, topping opponents by 10.5 points per game. They’re putting up 79.9 points per game to rank 47th in college basketball and are giving up 69.4 per outing to rank 100th in college basketball.
• The 35.5 rebounds per game Louisville averages rank 31st in college basketball, and are 6.0 more than the 29.5 its opponents record per outing.
• Louisville hits 2.3 more threes per contest than the opposition, 9.9 (28th in college basketball) compared to its opponents’ 7.6.
• The Cardinals rank 45th in college basketball with 102.1 points scored per 100 possessions, and 70th in college basketball defensively with 88.7 points conceded per 100 possessions.
• Louisville wins the turnover battle by 1.7 per game, committing 10.9 (143rd in college basketball) while its opponents average 12.6.

Virginia Tech Performance Insights

• The Hokies’ -70 scoring differential (being outscored by 2.6 points per game) is a result of putting up 69.1 points per game (296th in college basketball) while allowing 71.7 per outing (180th in college basketball).
• Virginia Tech wins the rebound battle by 1.9 boards on average. It collects 30.6 rebounds per game, 270th in college basketball, while its opponents pull down 28.7.
• Virginia Tech connects on 8.0 three-pointers per game (148th in college basketball) compared to its opponents’ 7.7. It shoots 35.7% from deep, and its opponents shoot 32.8%.
• Virginia Tech loses the turnover battle by 2.0 per game, committing 12.1 (268th in college basketball) while its opponents average 10.1.

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