Best Bets for NCAA Basketball Picks Against the Spread for Saturday, February 22
Published 8:33 pm Friday, February 21, 2025
The college basketball schedule on Saturday is not one to miss. Our computer model has provided picks against the spread for 10 games, including the Iowa State Cyclones squaring off against the Houston Cougars at Fertitta Center.
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Today’s NCAA Men’s Basketball Picks ATS
ATS Pick: Iowa State +12.5 vs. Houston
- Matchup: Iowa State Cyclones at Houston Cougars
- Time: 2 p.m. ET
- Date: February 22
- Computer Projection: Houston by 6.7 points (Bet now on BetMGM)
- Spread: Houston (-12.5)
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: LIU +1.5 vs. Le Moyne
- Matchup: Long Island Sharks at Le Moyne Dolphins
- Time: 4 p.m. ET
- Date: February 22
- Computer Projection: LIU by 3.3 points (Bet now on BetMGM)
- Spread: Le Moyne (-1.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Nicholls State -3.5 vs. UT Rio Grande Valley
- Matchup: UT Rio Grande Valley Vaqueros at Nicholls State Colonels
- Time: 4 p.m. ET
- Date: February 22
- Computer Projection: Nicholls State by 8.1 points (Bet now on BetMGM)
- Spread: Nicholls State (-3.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Saint Francis (PA) +1.5 vs. Fairleigh Dickinson
- Matchup: Fairleigh Dickinson Knights at Saint Francis (PA) Red Flash
- Time: 2 p.m. ET
- Date: February 22
- Computer Projection: Saint Francis (PA) by 2.9 points (Bet now on BetMGM)
- Spread: Fairleigh Dickinson (-1.5)
- TV Channel: NEC Front Row
ATS Pick: Cal Baptist +9.5 vs. Grand Canyon
- Matchup: Cal Baptist Lancers at Grand Canyon Antelopes
- Time: 8 p.m. ET
- Date: February 22
- Computer Projection: Grand Canyon by 5.6 points (Bet now on BetMGM)
- Spread: Grand Canyon (-9.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
Bet on this or any men’s college basketball matchup at BetMGM.
ATS Pick: Ole Miss +1.5 vs. Vanderbilt
- Matchup: Ole Miss Rebels at Vanderbilt Commodores
- Time: 3:30 p.m. ET
- Date: February 22
- Computer Projection: Ole Miss by 2.2 points (Bet now on BetMGM)
- Spread: Vanderbilt (-1.5)
- TV Channel: SEC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: Kentucky +9.5 vs. Alabama
- Matchup: Kentucky Wildcats at Alabama Crimson Tide
- Time: 6 p.m. ET
- Date: February 22
- Computer Projection: Alabama by 5.9 points (Bet now on BetMGM)
- Spread: Alabama (-9.5)
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: American -3.5 vs. Boston University
- Matchup: Boston University Terriers at American Eagles
- Time: 4 p.m. ET
- Date: February 22
- Computer Projection: American by 7.1 points (Bet now on BetMGM)
- Spread: American (-3.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: McNeese -10.5 vs. Texas A&M-CC
- Matchup: Texas A&M-CC Islanders at McNeese Cowboys
- Time: 5 p.m. ET
- Date: February 22
- Computer Projection: McNeese by 14.0 points (Bet now on BetMGM)
- Spread: McNeese (-10.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: West Virginia +11.5 vs. Texas Tech
- Matchup: West Virginia Mountaineers at Texas Tech Red Raiders
- Time: 1 p.m. ET
- Date: February 22
- Computer Projection: Texas Tech by 8.1 points (Bet now on BetMGM)
- Spread: Texas Tech (-11.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
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